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目的：观察围绝经桥本氏甲状腺炎患者雌二醇的改变并探讨其意义。方法选取围绝经期桥本氏甲状腺炎患者32例，围绝经期女性志愿者32例，在月经后第13d检测其雌二醇水平。检测患者甲功三项(FT3、FT4、TSH)，抗甲状腺自身抗体(TGAb、TMAb)指标诊断桥本氏甲状腺炎。结果围绝经期桥本氏甲状腺炎病例雌二醇284.47±82.17ng/L，对照组雌二醇169.62±61.05ng/L，两者相比有显著差异。患者血清E2与TGAb水平呈显著正相关(r=0.519，P <0.05)。结论围绝经期桥本氏甲状腺炎患者雌二醇水平相比对照组升高，推测雌激素可能在围绝经期妇女桥本氏甲状腺炎发病过程中起一定作用。“,”Objective To observe the perimenopausal patients with Hashimoto’s thyroiditis estradiol changes and explore its significance. Methods 32 female perimenopausal patients with Hashimoto’s thyroiditis, 32 perimenopausal women volunteers, detect the level of estradiol after 13 days of the period. Detection of three thyroid function parameters, anti-thyroid autoantibodies parameters for the diagnosis of Hashimoto’s thyroiditis. Results The estradiol level of perimenopause Hashimoto’s thyroiditis patients is 284.47±82.17ng/L, and the control group is 169.62±61.05ng/L, which is a significant difference. TGAb and E2 levels were positively correlated(r=0.519, P <0.05). Conclusion The perimenopausal patients with Hashimoto’s thyroiditis elevated estradiol levels compared to the control group, suggesting that estrogen may in perimenopausal women Hashimoto’s thyroiditis play a role in the pathogenesis.