论文部分内容阅读
为阐明胺碘酮及其活性代谢物脱乙胺碘酮的血药浓度对预见副作用的价值,作者研究109例室性或室上性心律失常患者.其中男69例,女40例,平均年龄66.4岁,平均治疗时间25个月.结果96例报告了副作用,其中63例出现2个以上副作用.这些副作用包括无症状肝功能试验异常53例(48.6%)、甲状腺机能减退症15例(13.7%)、甲状腺毒症2例(1.8%)、皮肤副作用(光过敏、脱发、蓝灰色脸)34例(31.2%)、无症状甲状腺功能试验异常27例(24.8%)、神经副作用(周围神经病和头晕)26例(23.9%).在甲状腺功能试验异常者中,女
To elucidate the value of plasma concentrations of amiodarone and its active metabolite deethionate for predicting side effects, we studied 109 patients with ventricular or supraventricular arrhythmias, including 69 males and 40 females with an average age of 66.4 years and average duration of treatment was 25 months.Results 96 patients reported side effects and 63 of them had more than two side effects.These side effects included asymptomatic liver function test abnormalities in 53 patients (48.6%), hypothyroidism in 15 patients (13.7 34 cases (31.2%) had asymptomatic thyroid function test abnormalities, 27 cases (24.8%) had asymptomatic thyroid function test, neurological side effects (peripheral neuropathy And dizziness) 26 cases (23.9%). In thyroid function test abnormalities, women