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Tum statin和 Canstatin是继 Restin、angiostatin和 endostatin之后最新发现的基底膜来源人胶原 肿瘤血管生成抑制因子。 Tumstatin来源于胶原 α3链 ,其 N-端 5 4～ 132氨基酸功能肽能够抑制内皮细胞增殖和诱导内皮细胞凋亡 ,N -端 197～ 2 15氨基酸 [α3( ) NC1185～ 2 0 3氨基酸 ]功能肽能够抑制多种恶性肿瘤细胞的增殖。 Canstatin是来源于 型胶原α2链的 2 4 k D的血管生成和肿瘤生长抑制因子 ,它能剂量依赖性抑制内皮细胞管状结构的形成 ,有效抑制内皮细胞的增殖和迁移 ,并能诱导内皮细胞凋亡。在小鼠移植瘤模型体内实验中 ,Tum-statin和 Canstatin都显示出对实体瘤生长的显著抑制作用
Tum statin and Canstatin are the newly discovered basement membrane-derived human collagen tumor angiogenesis inhibitors after Restin, angiostatin and endostatin. Tumstatin is derived from the α3 chain of collagen and its N - terminal 5 4 ~ 132 amino acid peptide can inhibit the proliferation of endothelial cells and induce the apoptosis of endothelial cells. Tumstatin has the function of 197 ~ 215 amino acids [α3 (NC1185 ~ 203 amino acids) Peptides can inhibit the proliferation of a variety of malignant cells. Canstatin is a 24 kD angiogenic and tumor growth-inhibiting factor derived from the α2 chain of type collagen. It can inhibit the formation of tubular structures in endothelial cells in a dose-dependent manner, effectively inhibiting the proliferation and migration of endothelial cells and inducing endothelial cell apoptosis Death. Tum-statin and Canstatin both showed significant inhibitory effects on the growth of solid tumors in vivo in a mouse xenograft model