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曾报告过中国拟青霉(CN80—2)的药理作用,本文仅报告它与生育调节有关的实验结果:1.雄性小鼠以CN80—21.08g/kg×14d灌胃(PO)后,再与雌性小鼠合笼交配,结果怀孕率与胎仔数均低于对照组;2.小鼠妊娠第1天起给药(PO)CN80—2 20/kg×7d,有显著的抗着床作用(P<0.01);3.实验证明CN80—2有极显著的抗雌激素活性(P<0.001);4.大鼠给予CN80—2(剂量方法同小鼠)后,其血将雌二醇浓度明显降低而血浆孕酮浓度仅轻度下降;5.小鼠给予CN80—2 80g/kg一次灌胃,无明显毒牲。
The pharmacological effects of Paecilomyces chinensis (CN80-2) have been reported in China. This article only reports its experimental results related to fertility regulation: 1. Male mice were orally (PO) fed with CN80-21.08g/kg x 14d. Mating with female mice in a cage, the results of pregnancy rate and fetal number were lower than the control group; 2. The mice were given (PO) CN80-2 20/kg×7d on the first day of gestation and had significant anti-implantation effect. (P<0.01); 3. Experiments show that CN80-2 has very significant anti-estrogenic activity (P<0.001); 4. Rats give CN80-2 (dose method is the same as mice), its blood will estradiol The concentration of plasma progesterone decreased significantly and the concentration of plasma progesterone decreased only slightly. 5. The mice were given CN80-2 80g/kg gavage once, and there was no obvious toxicity.