论文部分内容阅读
目的:探讨兔严重胸腹伤后早期莫沙必利促肠道动力治疗对胃肠道缺血性损害的影响。方法:采用BIM-IV型生物撞击机建立实验性胸腹撞击伤动物模型,将30只新西兰兔分为正常对照组、创伤组和创伤促动力组,观察门静脉血流量、外周静脉和门静脉乳酸水平及胃和小肠黏膜形态学变化。结果:创伤促动力组门静脉血流量下降程度明显较小(P<0.05),外周静脉和门静脉血乳酸浓度升高程度明显低于创伤组(P<0.01),并且胃黏膜损害较轻。结论:兔严重胸腹伤后早期采用莫沙必利促胃肠道动力治疗对改善胃肠道缺血性损害有一定的保护作用。
Objective: To investigate the effect of early aggressive Mosapride on gastrointestinal ischemic injury in rabbits with severe chest and abdomen injury. METHODS: Thirty-eight New Zealand rabbits were divided into normal control group, trauma group and trauma-promoting group by BIM-IV biological impact machine. The portal vein blood flow, peripheral vein and portal vein lactic acid level And gastric and intestinal mucosal morphological changes. Results: The portal vein blood flow decreased significantly in the traumatic motility group (P <0.05). The levels of peripheral lactate and portal vein lactic acid in the peripheral blood and portal vein were significantly lower than those in the trauma group (P <0.01). Conclusion: The early use of Mosapride to promote gastrointestinal motility after severe chest and abdomen injury in rabbits has a protective effect on improving gastrointestinal ischemic injury.