胎膜早破(PRM)仍是早产主要原因之一,而早产又导致较高的胎儿发病率与死亡率。PRM有一定潜在发病条件,如局部感染、宫颈功能不全以及社会经济条件差。尽管如此,但多数病例的早产病因仍不明。 Parry-Jones等曾证实在维持胎膜的完整性上,胎膜的弹性比张力更重要。Lavery等曾认为羊水渗透性的变化可能影响胎膜弹性的粘性组成部分。近已证实在羊水、绒毛膜、蜕膜和/或羊膜都有较高的催乳素水平。在这些组织中,催乳素的重要作用之一,可能是与羊水的电解质渗透性和容量的调节有关。本研 Premature rupture of membranes (PRM) is still one of the main causes of preterm birth, and premature birth in turn lead to higher fetal morbidity and mortality. PRM has certain potential morbidity conditions, such as localized infections, cervical insufficiency, and poor socioeconomic conditions. However, the cause of preterm birth in most cases is still unknown. Parry-Jones et al. Have demonstrated that fetal membranes are more elastic than tensile in maintaining the integrity of the membranes. Lavery et al. Have suggested that changes in amniotic fluid permeability may affect the viscous component of fetal membrane elasticity. It has been confirmed in amniotic fluid, chorion, decidua and / or amniotic membrane have a higher prolactin levels. In these tissues, one of the important effects of prolactin may be related to the regulation of amniotic fluid electrolyte permeability and volume. This research