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本实验试图以在锦州饲养的大鼠研究氟化物对甲状腺的影响及其可能的机制。给缺碘或不缺碘的大鼠腹腔注射0.5%NaF,以观察氟对甲状腺碘化酪氨酸及碘化甲腺原氨酸分布的改变。注射 NaF 的大鼠甲状腺~(125)I—T_3明显低于对照组;D~(125)IT 和 M~(125)IT+D~(125)IT/~(125)I—T_3+~(125)I—T_4比值明显高于对照组。这一改变与 Stolc′s 的实验结果相一致。M~(125)IT+D~(125)IT/~125I—T_3+~(125)I—T_4比值的高低表明氟对甲状腺激素生物合成的短期影响是阻抑了激素的偶联过程。而氟对甲状腺~(127)碘分布的影响则不明显。
This experiment attempted to study the effects of fluoride on the thyroid gland and its possible mechanism in rats raised in Jinzhou. 0.5% NaF was intraperitoneally injected into rats with or without iodine deficiency to observe the changes of the distribution of thyroid iodine tyrosine and thyronine iodide. The level of ~ (125) I-T_3 in thyroid in rats injected with NaF was significantly lower than that in the control group; D 125 and IT 125 125 IT- 125 ) I-T_4 ratio was significantly higher than the control group. This change is consistent with Stolc’s experimental results. The level of M ~ (125) IT + D ~ (125) IT / ~ 125I-T_3 + ~ (125) I-T_4 indicates that the short-term effect of fluorine on thyroid hormone biosynthesis is the suppression of the hormone coupling process. The fluorine on the thyroid ~ (127) iodine distribution is not obvious.