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目的探讨新疆哈萨克族食管癌的发生与人类乳头状瘤病毒感染相关性。方法选取新疆哈萨克族食管癌患者的石蜡组织标本40例作为研究组,并选取同期的40例正常食管黏膜为对照组,对切片进行组织学观察分型,分析食管癌与人类乳头状瘤病毒感染相关性。结果研究组HPV-16的阳性检出率为57.5%,对照组HPV-16的阳性检出率为30.0%,两组比较,差异有统计学意义(P<0.05)。Ⅰ+Ⅱ期HPV-16检出阳性率54.55%,Ⅲa期HPV-16检出阳性率58.82%,Ⅲb期HPV-16检出阳性率66.67%,TNM分期与食管鳞状细胞癌组织中HPV-16的阳性率间对比,差异无统计学意义(P>0.05)。结论新疆哈萨克族食管癌发病过程与HPV-16感染具有一定关系,但HPV-16感染与食管癌的组织分化程度无明显的相关性。
Objective To investigate the relationship between the occurrence of esophageal cancer and human papillomavirus infection in Xinjiang Kazak. Methods Forty paraffin-embedded specimens of Kazakh Kazakh patients with esophageal cancer were selected as the study group. Forty normal esophageal mucosas of the same period were selected as the control group. Histological observation was performed on the sections to analyze the relationship between esophageal cancer and human papillomavirus Correlation. Results The positive rate of HPV-16 in the study group was 57.5%. The positive rate of HPV-16 in the control group was 30.0%. There was significant difference between the two groups (P <0.05). The positive rate of HPV-16 was 54.55% in stage Ⅰ + Ⅱ, the positive rate of HPV-16 in stage Ⅲa was 58.82%, the positive rate of HPV-16 in stage Ⅲb was 66.67%. The positive rate of HPV-16 in esophageal squamous cell carcinoma 16 positive rate between the contrast, the difference was not statistically significant (P> 0.05). Conclusion The incidence of esophageal cancer in Xinjiang Kazak is related to HPV-16 infection, but there is no significant correlation between HPV-16 infection and the degree of tissue differentiation of esophageal cancer.