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目的观察内镜注射治疗联用不同剂量的奥美拉唑（ OME）及单用 OME对消化性溃疡活动性出血患者的疗效。方法采用随机对照的方法。把 101例内镜下有活动性出血的消化性溃疡出血患者，随机分为 3组，分别接受：①内镜注射止血治疗联用每天 2次静脉注射 OME 40 mg，疗程 5 d；②内镜注射止血治疗联用每天 1次静脉注射 OME 40 mg，疗程 5 d；③单用每天 2次静脉注射 OME 40 mg，疗程 5 d。治疗期间观察患者的止血时间、输血量、再出血情况及住院时间。结果 3组患者的再出血率为 3/35（ 8.6％）， 9/32（ 28.1％）， 15/34（ 44.1％），差异有显著性（ P< 0.05）；手术率 1/35（ 2.9％）， 2/32（ 6.3％）， 7/34（ 20.6％），差异有显著性（ P< 0.05）；死亡率 0/34（ 0％）， 1/32（ 3.1％）， 1/34（ 2.9％），差异无显著性（ P >0.05）；输血量（ 3.7± 2.7）单位（每单位 =200m1），（ 5± 2.5）单位，（ 2.5± 2.4）单位，差异无显著性（ P >0.05）；止血时间分别为（ 1.8± 1.5） d，（ 3.8± 1.9） d，（ 5.5± 2.1） d，差异有显著性（ P< 0.05）；住院时间（ 8.7± 2.5） d，（ 15.7± 6.9） d，（ 17.1± 8.3） d，差异有显著性（ P< 0.05）。结论内镜注射治疗联用每天 2次静脉注射 40 mg OME疗效?
Objective To observe the effect of endoscopic injection combined with different doses of omeprazole (OME) and single OME on patients with active peptic ulcer bleeding. Methods Randomized controlled methods. 101 patients with active bleeding endoscopic peptic ulcer bleeding patients were randomly divided into three groups were: ① endoscopic injection of hemostasis combined with intravenous OME 40 mg twice daily for 5 days; ② endoscopic Injection of hemostasis combined with daily intravenous OME 40 mg, treatment 5 d; ③ single intravenous administration of OME 40 mg twice daily for 5 days. Hemostatic time, blood transfusion, rebleeding and hospital stay were observed during treatment. Results The rate of rebleeding was 3/35 (8.6%), 9/32 (28.1%) and 15/34 (44.1%) in the three groups, with a significant difference (P <0.05) (0%), 1/32 (3.1%), 1/34 (0%), 2/32 (6.3%) and 7/34 (20.6% (P <0.05). There was no significant difference in the blood transfusion volume (3.7 ± 2.7) units (200m1), (5 ± 2.5) units and (2.5 ± 2.4) (P> 0.05). The bleeding time was (1.8 ± 1.5) days, (3.8 ± 1.9) days and (5.5 ± 2.1) days respectively. There was significant difference between the two groups ± 6.9) d, (17.1 ± 8.3) d, the difference was significant (P <0.05). Conclusion Endoscopic injection combined with intravenous injection of 40 mg OME twice a day?