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微生物在人体内及体表无处不在,已有研究表明,定植于口腔、胃肠道和生殖道的共生细菌是人类免疫系统的重要组成部分,但在感染HIV后这些部位的微生物组会发生不同程度的改变。近年来随着分子生物技术(如高通量测序、荧光定量PCR等)的不断发展和应用,使人们从组学角度对HIV/AIDS感染患者口腔、胃肠道和生殖道的细菌成份、细菌病原体和HIV病毒间的相互关系,以及微生物组在HIV感染个体中产生的作用有了更加深入和全面的认识,作者对人类微生物组与HIV感染的研究现状进行综述。
Microbes are ubiquitous in the body and on the surface of the body. Studies have shown that commensal bacteria colonized in the oral, gastrointestinal and reproductive tracts are an important part of the human immune system, but microbial communities in these areas occur after HIV infection Different degrees of change. In recent years, with the continuous development and application of molecular biotechnology (such as high-throughput sequencing, fluorescence quantitative PCR, etc.), people from the perspective of histology of HIV / AIDS infected patients oral, gastrointestinal and genital bacteria, bacteria The relationship between pathogens and HIV, as well as the role of microbial groups in HIV-infected individuals have a more in-depth and comprehensive understanding of the human microbiome and HIV infection status of the review.