本文首先从R·Robinson关于某些吲哚类生物碱起源于色胺-儿茶酚的学说出发,设计了一条首先合成色胺-儿茶酚衍生物,然后通过光氧化开儿茶酚环得到钩吻素子可能的前体的路线。本论文完成了这方面的研究以后,发觉由于光氧化开儿茶酚环的收率较低,随之而来的立体化学问题难以解决,根据这条路线完成钩吻素子的全合成十分困难,从而重新考虑了另一条钩吻素子合成的路线。 In this paper, firstly, starting from R. Robinson’s theory that some indole alkaloids originated from tryptamine-catechol, a first tryptamine-catechol derivative was synthesized, and then the catechol ring was obtained by photooxidation The route of the kissing koji precursor. After completing the research in this field, we found that due to the low yield of catechol ring by photooxidation and the consequent stereochemical problems that are difficult to be solved, it is very difficult to complete the total synthesis of koumissin according to this route. Which reconsidered another route of koji synthesis.