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目的探讨低分子肝素辅助硫酸镁联用对子痫前期的临床疗效。方法将我院子痫前期患者120例随机分为观察组和对照组各60例。对照组给予单纯的硫酸镁治疗,观察组在硫酸镁方案上联合使用低分子肝素,比较两组患者妊娠结局及临床指标,分析疗效及安全性。结果观察组宫产、胎窘、新生儿窒息、新生儿呼吸窘迫综合症和围产儿死亡率明显低于对照组,组间差异有统计学意义(P<0.05)。结论单用硫酸镁治疗疗效差于硫酸镁联用低分子肝素,并发症发生率也较高,联用方案对母婴意义较大,推荐临床使用。
Objective To investigate the clinical effect of low molecular weight heparin combined with magnesium sulfate on preeclampsia. Methods 120 patients with preeclampsia in our hospital were randomly divided into observation group and control group of 60 cases. The control group was treated with simple magnesium sulfate. The observation group combined with low molecular weight heparin on the magnesium sulfate regimen. The pregnancy outcome and clinical indexes of the two groups were compared to evaluate the efficacy and safety. Results In the observation group, the uterus, fetal distress, neonatal asphyxia, neonatal respiratory distress syndrome and perinatal mortality were significantly lower than those in the control group. There was significant difference between the two groups (P <0.05). Conclusion Single magnesium sulfate treatment with poor efficacy of magnesium sulfate combined with low molecular weight heparin, the complication rate is also higher, combined with the program on the maternal and child more meaningful, recommended for clinical use.