雄黄是常用中药,临床应用广泛,同时也是国务院在《医疗用药毒性药品管理办法》中特别规定的28种毒性中药之一,因其含有砷,使著名/常用中成药(牛黄解毒片,安宫牛黄丸,六神丸等)的安全性问题受到了国内外医学界的质疑,影响了含雄黄中成药的国际声誉。为提高临床用药的安全性及合理性,对雄黄及其复方的毒性研究文献进行统计和综述。 Realgar is commonly used in traditional Chinese medicine. It is widely used in clinic. It is also one of the 28 toxic traditional Chinese medicines specially prescribed by the State Council in the Measures for the Administration of Toxic Drugs for Medical Treatment. As it contains arsenic, realgar (known as Niuhuang Jiedu Tablet, An Gong Niuhuang Wan, Liushen Wan, etc.) have been questioned by medical circles at home and abroad, affecting the international reputation of realgar containing realgar. In order to improve the safety and rationality of clinical medication, the literature on toxicity study of realgar and its compound was summarized and summarized.