肽类激素一直被认为是与其细胞浆膜上的受体结合而发挥作用的。但近二、三年来,陆续发现在细胞内各亚细胞器上肽类激素(如血管紧张素Ⅱ、胰岛素、EGF和催乳素)受体的存在。最近,Hocher等证实,在大白鼠肝细胞核和高尔基氏体上有高亲合力内皮素(ET)-1受体。他们首先提取高纯度的肝细胞膜、核和高尔基氏体,并经电镜和标志酶(葡萄糖-6-磷酸酶、5- Peptide hormones have long been thought to play a role in binding to receptors on their plasma membrane. But nearly two or three years, one after another found in the cell subcellular organelles on the presence of peptide hormones (such as angiotensin Ⅱ, insulin, EGF and prolactin) receptors. Recently, Hocher et al. Demonstrated that there is a high avidity endothelin (ET) -1 receptor in rat liver nuclei and Golgi apparatus. They first extracted high-purity hepatic cell membranes, nuclear and Golgi apparatus, and electron microscopy and marker enzymes (glucose-6-phosphatase, 5-