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目的探讨丹参联合柳氮磺胺吡啶(SASP)在治疗溃疡性结肠炎中的作用。方法将60例溃疡性结肠炎患者随机分为治疗组和对照组各30例,对照组给予口服柳氮磺胺吡啶治疗,治疗组在此基础上加用丹参粉口服。6周后比较临床症状、内镜及组织学疗效。结果对照组与治疗组临床症状总有效率分别为76.6%和96%,两组比较差异有显著性(P<0.01);内镜下炎症程度改善总有效率分别为73.3%和90%,两组比较差异有显著性(P<0.01);组织学炎症改善总有效率分别为73.3%和90%。两组比较差异有显著性(P<0.01)。结论丹参联合SASP治疗溃疡性结肠炎可明显提高治愈率。
Objective To investigate the effect of Salvia miltiorrhiza combined with sulfasalazine (SASP) in the treatment of ulcerative colitis. Methods Sixty patients with ulcerative colitis were randomly divided into treatment group (30 cases) and control group (30 cases). Patients in the control group were treated with sulfasalazine orally. On the basis of this study, the treatment group was given Salvia miltiorrhiza powder orally. Six weeks later, clinical symptoms, endoscopic and histological effects were compared. Results The total effective rates of the clinical symptoms in the control group and the treatment group were 76.6% and 96%, respectively, with significant difference between the two groups (P <0.01). The total effective rates of endometrial inflammation were 73.3% and 90% (P <0.01). The total effective rate of histological inflammation improvement was 73.3% and 90% respectively. There was significant difference between the two groups (P <0.01). Conclusion Salvia combined with SASP treatment of ulcerative colitis can significantly improve the cure rate.