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青蒿素(1)是由我国民间草药青蒿中提取出的含有过氧基团的新型倍半萜内酯,具有突出的抗疟作用。它的结构系由我国科学家测定的,它的化学全合成也已同时独立地由我国和瑞士化学家完成。为了解自然界合成这类物质的途径,并作为仿生合成的借鉴,我们开展了它的生物合成的研究。近十多年来~(13)CNMR技术的发展促进了稳定同位素~(13)C在生物合成研究中的应用。L本文报告我们采用二维核磁共振技术研究青蒿素~1HNMR和~(13)CNMR谱线归属的结果,这将为以后~13C中间体的生物转化产物提供鉴定的基础。在青蒿素结构的研究中,刘静明等曾初步讨论了它的~1HNMR和~(13)CNMR谱。随后王
Artemisinin (1) is a new type of sesquiterpenoid lactone with peroxy group extracted from Artemisia annua L., a folk herbal medicine in our country, and has outstanding anti-malarial effect. Its structure is determined by our scientists, and its chemical synthesis has also been completed independently by both our country and Swiss chemists. In order to understand the ways of synthesizing such substances in nature and to learn from the biomimicry, we carried out the research on its biosynthesis. In recent ten years, the development of ~ (13) CNMR technology has promoted the application of stable isotope ~ (13) C in biosynthesis research. L This paper reports the results of two-dimensional nuclear magnetic resonance (NMR) techniques for the study of the attribution of artemisinin ~ 1HNMR and ~ (13) CNMR spectra, which will provide the basis for the identification of bioconverted products of ~ 13C intermediates. In the study of artemisinin structure, Liu Jingming et al. First discussed its ~ 1HNMR and ~ (13) CNMR spectra. Then the king