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作者报道了一起在小儿科病房的工作人员和住院患者中发生的微小病毒B19爆发流行。这家病房共有58名(男13人,女45人)工作人员,12例免疫损伤儿童(7例骨髓移植者,5例肾脏移植者)在该病房住院。1990年8月9日,病房中的1名护士出现皮疹,并有发热、关节痛、腹泻等。此后在工作人员中又出现了类似的病人,此时怀疑微小病毒B_(19)感染,对全部工作人员,住院患者及密切接触者采集了血清标本,用放射免疫法测定B_(19)IgM和IgG,用斑点杂交试验检测B_(19)DNA,阳性者进一步用PCR证实。
The authors report the outbreak of parvovirus B19 that occurred in both pediatric ward staff and hospitalized patients. A total of 58 staff (13 males and 45 females) were employed in the ward and 12 immunocompromised children (7 bone marrow transplant recipients and 5 renal transplant recipients) were hospitalized in the ward. On August 9, 1990, a nurse in the ward developed a rash and fever, joint pain, diarrhea and the like. A similar patient then appeared in the staff and the suspected B 19 virus infection was suspected. Serum samples were collected from all staff, inpatients and close contacts, B 19 IgM was determined by radioimmunoassay IgG, B 19 DNA was detected by dot blot hybridization, and the positive samples were confirmed by PCR.