目的:探讨ER,PR,p53和Ki67在子宫内膜癌中的表达及意义。方法:采用免疫组织化学方法检测135例子宫内膜癌肿瘤中ER,PR,p53和Ki67的表达情况。结果:ER阳性率74.1%,PR阳性率79.3%,p53阳性率25.9%,Ki67阳性率28.1%。ER和PR阳性率随病理分期增加、分化级别降低及淋巴结转移而下降;p53和Ki67阳性率随病理分期增加、组织分化级别降低及淋巴结转移而增加。结论:联合检测ER,PR,p53和Ki67在子宫内膜癌中表达情况,可更好判断患者预后。 Objective: To investigate the expression and significance of ER, PR, p53 and Ki67 in endometrial carcinoma. Methods: Immunohistochemistry was used to detect the expression of ER, PR, p53 and Ki67 in 135 cases of endometrial carcinoma. Results: The positive rate of ER was 74.1%, the positive rate of PR was 79.3%, the positive rate of p53 was 25.9%, and the positive rate of Ki67 was 28.1%. The positive rates of ER and PR decreased with the pathological stage, differentiation level and lymph node metastasis. The positive rates of p53 and Ki67 increased with the increase of pathological stage, histological grade and lymph node metastasis. Conclusion: The combined detection of ER, PR, p53 and Ki67 expression in endometrial cancer, can better determine the prognosis of patients.