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目的:观察通心络胶囊联合西药氯吡格雷治疗老年冠心病中不稳定性心绞痛的临床疗效。方法:将诊断为冠心病不稳定性心绞痛的120例老年患者,随机平均分成60例观察组和对照组,观察组在常规治疗上口服通心络胶囊和氯吡格雷,对照组采用常规治疗的方法。观察治疗3个月后其临床疗效、心电图疗效、血液流变学及血脂的变化,观察患者用药前后持续时间、硝酸甘油消耗量、心绞痛发作次数、程度进行疗效比较。结果:观察组患者跟对照组在临床疗效之间的比较差异有统计学意义(P<0.05);观察治疗后两组心绞痛发作持续时间、频率以及硝酸甘油的用量均比治疗前效果明显改善,两者比较差异有统计学意义(P<0.05);用心电图观察对照组的疗效明显不如观察组(P<0.05);治疗后治疗组与对照组比较改善明显,两组比较差异性显著(P<0.05);治疗后观察组与对照组在血液流变学指标与血脂指标的比较上有显著性差异(P<0.05)。结论:通心络胶囊联合西药氯吡格雷治疗老年患者冠心病不稳定性心绞痛临床上疗效显著,并能很好的改善血液中流变学及血脂指标,安全系数较高。
Objective: To observe the clinical effect of Tongxinluo capsule combined with western medicine clopidogrel in the treatment of unstable angina pectoris in elderly patients with coronary heart disease. Methods: A total of 120 elderly patients diagnosed as unstable angina pectoris were randomly divided into observation group (60 cases) and control group. The observation group was given Tongxinluo capsule and clopidogrel on the conventional treatment. The control group was treated with routine treatment method. The clinical curative effect, electrocardiogram curative effect, hemorheology and blood lipid change were observed after 3 months of treatment. The duration of treatment, the consumption of nitroglycerin and the number of angina pectoris were observed before and after treatment. Results: The difference of clinical curative effect between observation group and control group was statistically significant (P <0.05). The duration of angina pectoris, frequency and the dosage of nitroglycerin in both groups were significantly improved after treatment, The difference between the two groups was statistically significant (P <0.05). The electrocardiogram showed that the curative effect of the control group was significantly lower than that of the observation group (P <0.05). After treatment, the treatment group and the control group improved significantly <0.05). There was significant difference between hemorheology index and blood lipid index in the observation group and the control group after treatment (P <0.05). Conclusion: Tongxinluo capsule combined with clopidogrel in the treatment of coronary heart disease in elderly patients with unstable angina pectoris has a significant clinical effect, and can well improve the blood rheology and blood lipid indicators, a higher safety factor.