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Two new α-aminophosphonate derivatives containing thieno[2,3-d]pyrimidine, diethyl(((6-ethyl-2-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)amino)(4-methoxyphenyl)methyl)phosphonate(1) and diethyl((4-bromophenyl)((6-ethyl-2-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)amino)methyl)phosphonate(2), have been synthesized by a facial phosphorylated reaction, and their structures were characterized by NMR, IR, HRMS and X-ray single-crystal diffraction. Compound 1(C21H28N3O5PS, Mr = 465.49) belongs to the orthorhombic system, space group P212121, with a = 10.83653(16), b = 12.04906(19), c = 18.0061(3) , V = 2351.06(6) 3, Z = 4, Dc = 1.315 g/cm3, μ = 2.177 mm-1, F(000) = 984.0, the final R = 0.0389 and w R = 0.0985 for all data. Compound 2(C20H25Br N3O4 PS, Mr = 514.37) belongs to the orthorhombic system, space group P212121, with a = 10.9187(5), b = 11.9522(4), c = 17.7667(7) , V = 2318.60(16) 3, Z = 4, Dc = 1.474 g/cm3, μ = 4.175 mm-1, F(000) = 1056.0, the final R = 0.0367 and w R = 0.0946 for all data.
Two new α-aminophosphonate derivatives containing thieno [2,3-d] pyrimidine, diethyl (6-ethyl-2-methyl-4- oxothieno [2,3- d] pyrimidin-3 (4H) (4-bromophenyl) (6-ethyl-2-methyl-4-oxothieno [2,3- d] pyrimidin-3 (4H) -yl) amino) methyl) phosphonate (2), have been synthesized by a facial phosphorylated reaction, and their properties were classified by NMR, IR, HRMS and X-ray single-crystal diffraction. Compound 1 (C21H28N3O5PS, Mr = 465.49) belongs to the orthorhombic system , space group P212121 with a = 10.83653 (16), b = 12.04906 (19), c = 18.0061 3, V = 2351.06 63, Z = 4, Dc = 1.315 g / cm3, 2.177 mm-1, F (000) = 984.0, the final R = 0.0389 and w R = 0.0985 for all data. Compound 2 (C20H25Br N3O4 PS, Mr = 514.37) belongs to the orthorhombic system, space group P212121, with a = V = 2318.60 (16) 3, Z = 4, Dc = 1.474 g / cm3, μ = 4.175 mm-1, F ) = 1056.0, the final R = 0.0367 and w R = 0.0946 for all data.