长期铅暴露对儿童海马和额叶~1H磁共振波谱(MRS)的影响

来源 :世界核心医学期刊文摘(神经病学分册) | 被引量 : 0次 | 上传用户:sfx158158
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The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate(neuronal den sity and mitochondrial metabolism), creatine +phosphocreatine (phosphate metabo lism), and choline(membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs con trols. The reductions were right frontal >left frontal > hippocampus but were the same bilaterally in the hippocampus. The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate (neuronal den sity and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabo lism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs con trols. The reductions were right frontal> left frontal> hippocampus but were the same bilaterally in the hippocampus.
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