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A polypseudorotaxane(PPR) nanoparticle was fabricated by the self-assembly of m PEG-protoporphyrin IX(PpIX) conjugate and a-CDs via the host-guest interaction.The nanoparticle loaded with anticancer drug doxorubicin(DOX) exerted synergistic photodynamic and chemotherapy.The nanoparticle was spherical with the mean size of 89 nm,the low critical micelle concentration(CMC) of DOX-loaded nanoparticle was 9.3 mg/m L and the drug loading content was 9.93%.The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species(ROS)cytotoxicity and chemotherapeutic efficacy to cancer cells.The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.