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目的 探讨综合治疗对多发性骨转移瘤缓解骨痛 ,改善生活质量的临床意义。方法 2 88例骨转移瘤患者用止痛性放疗、化疗、内照射治疗 (89Sr及 1 5 3Sm)、博宁 (Pamidronate)等综合治疗 ,并分组观察治疗后疼痛缓解及生活质量的变化。结果 89Sr结合止痛性放疗组疗效最佳 ,有效率达 94.1% ,与化疗组及化疗加博宁组比较有统计学差异 ;综合治疗组总有效率为 75 .4% ,高于单一治疗组 (P<0 .0 0 1) ;在 89Sr与 1 5 3Sm毒性反应比较中 ,1 5 3Sm毒性反应较大 ,且有统计学差异。结论 根据患者病灶及全身情况 ,制订综合治疗方案 ,选择放射性核素治疗及局部止痛性放疗 ,以达到多发性骨转移瘤最佳治疗效果。
Objective To explore the clinical significance of comprehensive treatment of bone metastasis with multiple bone metastases to relieve bone pain and improve quality of life. METHODS: Eighty-eight patients with bone metastases were treated with analgesic radiotherapy, chemotherapy, internal irradiation (89Sr and 153Sm) and Pamidronate, and the pain relief and quality of life were observed after treatment. Results 89Sr combined with analgesic radiotherapy group had the best curative effect and the effective rate was 94.1%. Compared with the chemotherapy group and the Chemin group, the total effective rate was 89.4%, which was higher than the single treatment group ( P <0 0 1 0) 1) In the comparison of toxicity between 89Sr and 153Sm, the toxicity of 153Sm was relatively large and there was a statistical difference. Conclusion According to the patient’s lesions and general conditions, formulate a comprehensive treatment plan, select radionuclide therapy and local analgesic radiotherapy to achieve the best therapeutic effect of multiple bone metastases.