人乳头状瘤病毒 (HumanPapillamaviruses ,HPV)为环状DNA病毒 ,编码 11种功能不同的基因产物 ,在病毒复制、感染机体及致病过程中起不同作用。HPV与人类许多疾病有关 ,其致病过程涉及病毒基因组的整合、病毒基因的激活 ,通过干扰宿主细胞的信号转导等途径 ,导致宿主细胞的异常增殖和恶变。HPV感染机体后可导致体液及细胞免疫应答等病理生理改变 Human papillomavirus (HPV), a circular DNA virus, encodes 11 different gene products that play different roles in viral replication, infection of the host and pathogenicity. HPV is involved in many human diseases. The pathogenic process involves the integration of the viral genome, the activation of viral genes, and the abnormal proliferation and malignancy of host cells by interfering with the signal transduction of host cells. HPV infection can lead to body fluids and cellular immune response and other pathophysiological changes