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目的α干扰素和苦参素联合治疗慢性乙型肝炎。方法将90例慢性乙型肝炎随机分为3组,1组30例α干扰素联合苦参素治疗;两组30例单用α干扰素治疗;3组30例单用苦参素治疗,疗程3～6个月。治疗前后定期检测肝功能、HBeAg、抗-HBe、HBV-DNA。结果联合治疗组HBeAg/抗-HBe转换率、HBV-DNA阴转率均显著高于单一药物组,差异有统计学意义(P<0.05)。结论α干扰素和苦参素联合治疗慢性乙型肝炎有显著疗效,值得临床推广。
Objective Interferon and oxymatrine combined treatment of chronic hepatitis B. Methods Ninety patients with chronic hepatitis B were randomly divided into three groups, one group of 30 interferon alpha combined with oxymatrine treatment; two groups of 30 patients treated with alpha interferon alone; three 30 patients treated with oxymatrine alone, treatment 3 to 6 months. Liver function, HBeAg, anti-HBe and HBV-DNA were detected regularly before and after treatment. Results The HBeAg / anti-HBe conversion rate and HBV-DNA negative conversion rate in the combined treatment group were significantly higher than those in the single drug group (P <0.05). Conclusion IFN-α and oxymatrine combined treatment of chronic hepatitis B has a significant effect, worthy of clinical promotion.