帕金森综合征与肌萎缩侧束硬化两病合并发生是极少见的。文献报道仅7个家族14例。作者等遇到一家兄弟5人,除最小的弟弟近年始觉两下肢行走不便,颇似他哥哥们初发病时的症状,但体查未发现明显神经系阳性征外,其余兄弟4人先后发生缓慢进行性肢体僵硬,震颤,言语不清,饮食呛咳等类似症 Parkinson’s disease and amyotrophic lateral sclerosis combined with the occurrence of two diseases is rare. Literature reported only seven families in 14 cases. The author encountered a brother 5, in addition to the youngest brother in recent years, two lower extremities began to feel inconvenience of walking, quite similar to the symptoms of his elder brother’s first attack, but the physical examination found no obvious neurological syndrome, the other four brothers have occurred Slow progressive limb stiffness, tremor, ill-defined, cough and other symptoms of diet