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目的:探讨不同人乳头瘤病毒(human papillomavirus,HPV)基因亚型的感染情况及高危型HPV亚型感染与子宫颈疾病间的关系。方法:选取我院妇科门诊就诊的1 669例患者行HPV基因分型检测,HPV检测结果为阳性的患者在知情同意后行阴道镜检查,对镜下表现可疑的患者进一步行子宫颈组织活检。结果:1 669例患者中HPV阳性567例,总HPV阳性率为33.97%,HPV亚型感染率前5位由高到低依次为HPV-16(9.05%)、HPV-52(7.85%)、HPV-58(6.29%)、HPV-CP8304(5.81%)、HPV-53(3.71%)。不同年龄段中,≤30岁者为HPV感染的高峰年龄段。在567例HPV阳性的患者中,高危型HPV亚型感染患者共454例,占总HPV感染者的80.07%。病灶组织活检结果为高级别鳞状上皮内病变(high-grade squamous intraepithelial lesion,HSIL)以上的患者中,高危型HPV亚型感染的前5位由高到低依次为HPV-16(58例)、HPV-52(26例)、HPV-58(25例)、HPV-18(10例)、HPV-31(6例)。结论 :HPV感染人群高峰有年轻化趋势,HPV基因分型检测在子宫颈疾病诊断中具有重要价值,其中HPV-16、HPV-52、HPV-58、HPV-18、HPV-31与子宫颈癌的关系密切。
Objective: To investigate the infection of different human papillomavirus (HPV) genotypes and the relationship between high-risk HPV subtypes and cervical diseases. Methods: One hundred and sixty-six patients with gynecological clinic in our hospital were examined by HPV genotyping. Patients with positive HPV test underwent colposcopy with informed consent and biopsy of cervical tissue in patients with microscopic findings. Results: The HPV positive rate was 33.97% in 1 669 cases. The top 5 HPV infection rates were HPV-16 (9.05%), HPV-52 (7.85%), HPV-58 (6.29%), HPV-CP8304 (5.81%), HPV-53 (3.71%). Different age groups, ≤ 30 years of age is the peak age of HPV infection. Of the 567 HPV-positive patients, 454 were high-risk HPV subtypes, accounting for 80.07% of all HPV infections. Among the 5 patients with high-grade squamous intraepithelial lesion (HSIL) whose lesions were biopsied, the top 5 high-risk HPV subtypes were HPV-16 (58 cases) , HPV-52 (26 cases), HPV-58 (25 cases), HPV-18 (10 cases) and HPV-31 (6 cases). Conclusions: The peak of HPV infection is young, and HPV genotyping is of great value in the diagnosis of cervical diseases. HPV-16, HPV-52, HPV-58, HPV-18, HPV-31 and cervical cancer Close relationship.