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1例54岁女性患者因类风湿关节炎、骨关节病服用来氟米特20 mg,1次/d。5个月后加服瘀血痹胶囊4粒,3次/d。第2次服用瘀血痹胶囊后约5 h,患者体温升高至38.8℃,手掌出现红疹并迅速遍及全身,伴咽痛、头晕、胸闷、乏力、视觉异常,血压86/47 mm Hg(1 mm Hg=0.133kPa)。给予葡萄糖酸钙、维生素C、氢化可的松琥珀酸钠、氯雷他定等抗过敏治疗,并服用中药煎剂。入院第2天实验室检查:外周血白细胞计数18.3×10~(12)/L,中性粒细胞0.96;C反应蛋白148 mg/L;降钙素原2.16 ng/ml;丙氨酸转氨酶54 U/L,天冬氨酸转氨酶55 U/L,直接胆红素7.8μmol/L,尿素11.2 mmol/L,肌酐209μmol/L。X线胸片示肺部感染,给予头孢西丁钠静脉滴注。入院第3天,患者体温恢复正常,出现过敏性口炎。给予康复新液口服,并用复方氯己定含漱液漱口。入院第8天,患者过敏症状消失。
A 54-year-old female patient received leflunomide 20 mg once daily for rheumatoid arthritis and osteoarthrosis. Add blood stasis capsule 4 after 5 months, 3 times / d. The second time taking blood stasis Bi capsule about 5 h, the patient’s temperature rose to 38.8 ℃, the palpebral rash and rapid spread throughout the body, with sore throat, dizziness, chest tightness, fatigue, visual abnormalities, blood pressure 86/47 mm Hg 1 mm Hg = 0.133 kPa). To give calcium gluconate, vitamin C, hydrocortisone sodium succinate, loratadine anti-allergy treatment, and taking traditional Chinese medicine decoction. Laboratory examination on the second day of admission: peripheral blood leukocyte count 18.3 × 10-12 / L, neutrophil 0.96; C-reactive protein 148 mg / L; procalcitonin 2.16 ng / ml; alanine aminotransferase 54 U / L, aspartate aminotransferase 55 U / L, direct bilirubin 7.8 μmol / L, urea 11.2 mmol / L, creatinine 209 μmol / L. X-ray showed lung infection, given cefoxitin sodium intravenous infusion. On the third day after admission, the patient’s body temperature returned to normal with an allergic stomatitis. To rehabilitation rehabilitation oral liquid, and with compound chlorhexidine gargle mouthwash. The first 8 days of admission, the patient’s allergic symptoms disappeared.