吞噬细胞是一组非特异性免疫细胞,包括单核/巨噬细胞、多形核白细胞(PMN)、NK细胞和星形细胞等,构成机体抵抗微生物的第一道防线。HIV-1对这些细胞的嗜向性表现在这些细胞表面表达两个重要的HIV-1协同受体CXCR4和CCR5。HIV-1感染使吞噬细胞吞噬功能缺陷,导致细胞凋亡,尤其在艾滋病(AIDS)晚期,易引起机会致病微生物的合并感染和重复感染。 Phagocytes are a group of nonspecific immune cells, including monocytes / macrophages, polymorphonuclear leukocytes (PMNs), NK cells and astrocytes, which form the body’s first line of defense against microorganisms. The tropism of HIV-1 to these cells is manifested by the expression of two important HIV-1 co-receptors, CXCR4 and CCR5, on the surface of these cells. HIV-1 infection phagocytosis phagocytosis defects, leading to apoptosis, especially in the late AIDS (AIDS), easily lead to the opportunistic pathogens of co-infection and repeated infections.