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目的分析阿托伐他汀联合氯吡格雷治疗脑血栓患者的疗效及对患者血液流变学与凝血功能的影响。方法选取平顶山市第一人民医院2014年9月—2016年6月收治的78例脑血栓患者,采用随机数字表法分为观察组(39例)和对照组(39例),两组均给予阿司匹林和阿托伐他汀治疗,观察组加用氯吡格雷治疗,治疗3个月后统计两组总有效率,并比较两组治疗前和治疗3个月后血液流变学指标[红细胞压积(PCV)、全血低切黏度(WBLSV)、全血高切黏度(HBV)、血浆黏度(PV)]、凝血功能指标[纤维蛋白原(FIB)、部分活化凝血活酶时间(APTT)]水平。结果观察组总有效率为92.31%,高于对照组64.10%,差异有统计学意义(P<0.05);观察组治疗3个月后WBLSV、HBV、PV与对照组相比,明显较低,差异有统计学意义(P<0.05);两组治疗3个月后FIB均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论脑血栓采用阿托伐他汀联合氯吡格雷治疗,可改善机体血液流变学状态和凝血功能,疗效显著。
Objective To analyze the effect of atorvastatin combined with clopidogrel on patients with cerebral thrombosis and its effect on hemorheology and coagulation function. Methods 78 patients with cerebral thrombosis admitted to the First People’s Hospital of Pingdingshan from September 2014 to June 2016 were randomly divided into observation group (39 cases) and control group (39 cases) by random number table, and both groups were given Aspirin and atorvastatin treatment, the observation group plus clopidogrel treatment, three months after treatment, the total effective rate of the two groups were statistically analyzed, and compared two groups before treatment and after 3 months of treatment hemorheological parameters [hematocrit PCV, WBLSV, HBV, and PV], coagulation index [fibrinogen (FIB), partial activated thromboplastin time (APTT)] Level. Results The total effective rate of the observation group was 92.31%, which was higher than that of the control group (64.10%), the difference was statistically significant (P <0.05); WBLSV, HBV and PV in the observation group were significantly lower than those in the control group The difference was statistically significant (P <0.05); FIB in both groups after 3 months of treatment decreased compared with before treatment, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Cerebral thrombosis with atorvastatin combined with clopidogrel treatment can improve the body’s blood rheology and coagulation, with a significant effect.