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以前认为无机的硝酸根和亚硝酸根阴离子是内源一氧化氮代谢的无活性最终产物。然而,近年研究显示这些所谓的无活性阴离子在体内通过再循环生成一氧化氮,区别于经典的L-精氨酸-一氧化氮合酶通路,是另一条重要的替代的一氧化氮源,特别在缺氧状态时。本文讨论了硝酸根-亚硝酸根-一氧化氮通路非常重要的生物功能,强调了那些提示硝酸盐和亚硝酸盐在一些病理条件下具潜在治疗作用的研究,例如在心肌梗死、卒中、全身和肺动脉高压症及胃溃疡等。
Inorganic nitrite and nitrite anions were previously thought to be inactive end products of endogenous nitric oxide metabolism. However, recent studies have shown that these so-called inactive anions, which are produced by the recycling of nitric oxide in the body, are distinguished from the classical L-arginine-nitric oxide synthase pathway as another important alternative source of nitric oxide, Especially in hypoxia. This article discusses the very important biological functions of the nitrate-nitrite-nitric oxide pathway, highlighting the studies that suggest potential therapeutic effects of nitrates and nitrites under some pathological conditions, such as myocardial infarction, stroke, general And pulmonary hypertension and gastric ulcer.