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目的:了解药物不良反应(ADR)的特点及规律,促进临床合理用药。方法:收集2008-01-2009-10378例ADR报告,对引起ADR的药品种类、给药途径、ADR所致器官损害、ADR患者的不良反应史等进行统计分析。结果:378例ADR报告中,抗生素ADR占37.3%,静脉滴注给药时发生ADR占88.62%。ADR的主要临床表现为皮疹、头晕、头痛及胃肠道反应。结论:应结合药物不良反应的特点和规律,严格把握用药适应证,加强用药监护,采取有针对性地监测和管理,尽量减少不良反应的发生。
Objective: To understand the characteristics and rules of adverse drug reaction (ADR) and to promote rational drug use in clinic. Methods: The ADRs of 2008-01-2009-10378 cases were collected to analyze the types of drugs that cause ADR, the route of administration, the organ damage caused by ADR, the adverse reaction history of ADR patients and so on. Results: In 378 cases of ADR, antibiotics ADR accounted for 37.3%, ADR accounted for 88.62% when administered intravenously. The main clinical manifestations of ADR rash, dizziness, headache and gastrointestinal reactions. Conclusion: The characteristics and laws of adverse drug reactions should be combined with the indications of drug use strictly, the monitoring of medication should be strengthened, the monitoring and management should be taken in order to minimize the adverse reactions.