【摘 要】
：
RNA modification has been recognized as a pivotal regulator that affects gene expression in a post-transcriptional manner.To date,more than 150 distinct types of RNA modification have been identi-fied,among which N6-methyladenosine (m6A) is the most abund
【机 构】
：
MOE Key Laboratory of Gene Function and Regulation,Guangdong Province Key Laboratory of Pharmaceutic
论文部分内容阅读
RNA modification has been recognized as a pivotal regulator that affects gene expression in a post-transcriptional manner.To date,more than 150 distinct types of RNA modification have been identi-fied,among which N6-methyladenosine (m6A) is the most abundant and best-characterized internal modification in mRNAs (Boccaletto et al.,2018).Benefit from the fast development of innovative technol-ogies,the prevalence of m6A has been reported and confirmed repeatedly in diverse organisms.Recent studies reveal that aberrant m6A modification is associated with various disease progressions such as carcinogenesis and tumorigenesis by disturbing the expres-sion of oncogenes and tumor suppressor genes (Tuncel and Kalkan,2019;Zhao et al.,2020).The m6A methyltransferase METTL3 is found to be overexpressed in acute myeloid leukemia (AML) (Barbieri et al.,2017;Vu et al.,2017),which consequently elevates the m6A level of B cell lymphoma 2 (BCL2) transcript and promotes the translation effi-ciency,leading to inhibition of cell differentiation (Vu et al.,2017).
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