控制及治疗革兰氏阴性杆菌菌血症和继发的内毒素休克是当前临床上面临的重要课题。近年来随着对内毒素致病机理的深入了解,已认识到肿瘤坏死因子(TNF)是其发挥毒力的重要媒介因子,并观察到抗TNF抗体对革兰氏阴性杆菌菌血症和内毒素休克有良好的预防和治疗效果。本文着重介绍有关这项研究的实验进展和相关理论。 Control and treatment of Gram-negative bacteremia and secondary endotoxic shock is clinically an important issue facing. In recent years, with the deep understanding of the pathogenesis of endotoxin, it has been recognized that tumor necrosis factor (TNF) is an important mediator of its virulence and anti-TNF antibodies against gram-negative bacilli and Toxic shock has a good preventive and therapeutic effect. This article focuses on the experimental progress and theory of the study.