In this paper, the precursor response characteristics of digital fluid caused by the Wenchuan M8. 0 and Yushu M7. 1 earthquakes are studied, and the response difference of the observations of Wuliying well to the two strong earthquakes is compared. The result shows that the abnormal fluid response has a certain relationship with earthquake size and epicenter distance. The greater the earthquake, and the closer it is to the epicenter from the observatory, the more sensitive the response will be to fluid anomalies. Abnormal Helium release was first observed before both strong earthquakes in the fluid precursor observation. The release intensity is related to earthquake magnitude; the larger the magnitude, the stronger the abnormal changes. The large change in He release in a short period after the Wenchuan earthquake may be related to the continuous activity of strong aftershocks and the structural adjustment after the earthquake. Helium release increased significantly after both earthquakes, as contributed by the abnormal deep-sited Helium release. However, this process may be connected to the annual change from July to September or the hot-reservoir type gas release in the Wuliying well. In the earthquake preparation process, a large number of deep-derived Helium is released into the geothermal system and the entire composition is changed. Temporally, this gas release appears later than fault-type gas release, and the disappearance time of this anomaly is also much later. The response difference of the fluid precursor to the two strong earthquakes may be related to differences of deep structural setting and dynamic mechanism. It also shows there is a stronger correlation between Wenchuan M8. 0 earthquake in the North-South Seismic Belt and North China region than the Yushu M7. 1 earthquake in the internal Qinghai-Tibetan plateau. Helium gas can be a sensitive indicator for monitoring abnormal deep-gas activity of the region where the observation station is located. Hence, observation and research should be strengthened in the future.