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本文对88例纤维源性肿瘤进行了核仁形成区蛋白定量研究,其中纤维瘤6例,瘤样纤维组织增生45例,纤维肉瘤37例。结果表明三种病变及其亚类核仁形成区蛋白均值有显著与高度显著性差异(P<0.05,P<0.001)。在随访的34例纤维肉瘤患者中,高核仁形成区蛋白均值患者(≥5)的生存时间显著短于低均值(<5)患者(P<0.05),5年生存率分别是20%与53%。因此,作者认为核仁形成区蛋白在鉴别纤维源性肿瘤及预测患者预后中均有一定实用价值。
In this paper, 88 cases of fibroid-derived tumors were studied for nucleolus formation protein, including 6 cases of fibroids, 45 cases of tumor-like fibroplasia, and 37 cases of fibrosarcoma. The results showed that there was a significant and highly significant difference in the protein mean values of the three lesions and their sub-categories (P<0.05, P<0.001). Among the 34 patients with fibrosarcoma who were followed-up, the survival time of patients with high nucleolar protein formation (≥5) was significantly shorter than that of patients with low mean (<5) (P<0.05), and the 5-year survival rate was 20 % and 53%. Therefore, the authors believe that nucleolar forming region proteins have certain practical value in identifying fibrogenic tumors and predicting patient prognosis.