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传统认为粗糙型抗体能提供抵抗异种光滑型革兰氏阴性菌及其脂多糖(LPS)的保护力。但对这种内毒素核心的保护性抗体的存在尚存异议。本文作者认为动物模型的选择及对其局限性的了解是保护性试验的关键,结果的解释需考虑毒性攻击的动态变化及抗体与LPS结合的总效能。LPS的物理性状及其寡糖侧链的取代程度均可影响其与LPS核心抗体的结合。LPS核心决定簇单克隆抗体的被动保护试验结果支持传统观点。
Traditionally, rough antibodies have been shown to provide protection against heterotypically smooth Gram-negative bacteria and their lipopolysaccharide (LPS). However, the existence of protective antibodies against this endotoxin core remains objectionable. The author believes that the choice of animal model and understanding of its limitations is the key to protective testing. Interpretation of results should take into account the dynamic changes of toxic attack and the total efficacy of antibody binding to LPS. The physical properties of LPS as well as the degree of substitution of its oligosaccharide side chains can affect its binding to the LPS core antibody. The passive protection test results of LPS core determinants of monoclonal antibodies support the traditional view.