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We analyzed 211 consecutive plasma B-type natriuretic peptide(BNP) measurements in 59 pediatric heart transplant patients along with echocardiographic and right ventricular endomyocardial biopsy samples. Patients with a biopsy specimen negative for rejection had significantly lower BNP levels than those patients with a biopsy positive(p≤0.04) for rejection. BNP significantly decreased with treatment(p≤0.007). BNP levels in the first year after heart transplantation in all patients were significantly greater than BNP levels after the first year in all patients(p< 0.001).
Patients with a biopsy specimen negative for rejection had significantly lower BNP levels than those patients with a biopsy positive (p≤0.04) for rejection. BNP levels were significantly reduced with treatment (p≤0.007). BNP levels in the first year after heart transplantation in all patients were significantly greater than BNP levels after the first year in all patients (p <0.001).