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目的探讨孕妇血清可溶性细胞间粘附分子1(sICAM1)在孕期不同阶段的变化规律及其与早产亚临床绒毛膜羊膜炎的关系。方法2004年4月至2005年1月在中南大学湘雅三医院采用酶联免疫吸附(ELISA)方法,检测48例早产临产孕妇(早产组)及70例正常健康孕妇(其中早孕组15例、中孕组15例、晚孕组20例、足月临产组20例),外周血中sICAM1质量浓度。早产组同时测定血C反应蛋白(CRP)及白细胞(WBC)计数,产后胎膜行病理检测。结果(1)sICAM1质量浓度在正常妊娠各阶段差异无显著性(P>0.05)。(2)早产绒毛膜羊膜炎孕妇sICAM1、CRP质量浓度及WBC计数显著高于非绒毛膜羊膜炎孕妇(P<0.05)。(3)母血清sICAM1质量浓度为247.56μg/L、CRP质量浓度12.75mg/L、WBC计数10.32×109/L可作为绒毛膜羊膜炎的诊断阈值。结论(1)孕妇血清sICAM1质量浓度与孕龄无关。(2)预测早产绒毛膜羊膜炎,sICAM1比CRP和RBC计数更可靠。
Objective To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM1) in different stages of pregnancy and its relationship with subclinical chorioamnionitis. Methods From April 2004 to January 2005, 48 pregnant women with preterm labor (premature labor group) and 70 normal healthy pregnant women (including 15 pregnant women with early pregnancy group) were detected by enzyme linked immunosorbent assay (ELISA) at Xiangya Third Hospital of Central South University. 15 cases in the second trimester group, 20 cases in the second trimester group, and 20 cases in the term labor group). The concentrations of sICAM1 in the peripheral blood were detected. The preterm birth group also measured the blood C-reactive protein (CRP) and white blood cell (WBC) count, postpartum fetal line pathological examination. Results (1) There was no significant difference in sICAM1 concentration between different stages of normal pregnancy (P> 0.05). (2) The sICAM1, CRP concentration and WBC count of pregnant women with premature chorioamnionitis were significantly higher than those of non-chorioamnionitis pregnant women (P <0.05). (3) The serum concentration of sICAM1 was 247.56μg / L, the concentration of CRP was 12.75mg / L, the WBC count was 10.32 × 109 / L, which could be used as the diagnostic threshold for chorioamnionitis. Conclusion (1) The serum concentration of sICAM1 in pregnant women has nothing to do with gestational age. (2) Predict premature chorioamnionitis, sICAM1 is more reliable than CRP and RBC counts.