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尽管脂质体作为药物载体已经在临床上获得巨大的成功,改善了患者的生活质量,但目前为止,只有很少的药物被成功加工成为脂质体制剂,用于临床研究。脂质体在体内容易被网状内皮系统清除,药物动力学性质差。此外,药物的靶向性传递以及在肿瘤细胞的释放也限制了脂质体制剂的发展。文章综述了近几年作者实验室在克服以上传统脂质体存在的缺点方面所做的研究工作,着重介绍两种新型的脂质体磷酸钙纳米粒和脂质体顺铂纳米粒的制备及其在抗肿瘤方面的应用。
Although liposomes have been clinically successful as drug carriers and have improved the patient’s quality of life, so far only very few drugs have been successfully processed into liposomal formulations for clinical research. Liposomes in the body easily reticuloendothelial system clearance, poor pharmacokinetic properties. In addition, targeted delivery of drugs as well as release in tumor cells also limits the development of liposomal formulations. In this paper, the author summarizes recent work done by author laboratories in overcoming the shortcomings of the above traditional liposomes, and focuses on the preparation of two new types of liposomal calcium phosphate nanoparticles and liposomal cisplatin nanoparticles Its anti-tumor applications.