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目的：探讨瘢痕疙瘩和增殖性瘢痕中血管内皮生长因子（ＶＥＧＦ）的表达及其意义。方法：应用免疫组织化学染色技术，以正常皮肤和正常瘢痕作对照，观察了瘢痕疙瘩和增殖性瘢痕中ＶＥＧＦ的表达。结果：瘢痕疙瘩和增殖性瘢痕角朊细胞均有大量ＶＥＧＦ表达，阳性细胞主要位于基底层，染色颗粒在细胞质内，真皮层少见阳性细胞。而正常皮肤和正常瘢痕中ＶＥＧＦ的表达均较弱，与瘢痕疙瘩或增殖性瘢痕比较均有显著差异。结论：瘢痕疙瘩和增殖性瘢痕基底层的角朊细胞大量ＶＥＧＦ表达，它可能与瘢痕疙瘩和增殖性瘢痕的形成密切相关。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in keloid and hypertrophic scar and its significance. Methods: The normal skin and normal scars were used as controls to detect the expression of VEGF in keloid and hypertrophic scars by immunohistochemical staining. Results: The expression of VEGF in keloid and keratinocytes of proliferating scar were high. The positive cells mainly located in the basal layer. The staining granules were rare in the cytoplasm and the dermis. The normal skin and normal scars in the expression of VEGF are weak, and keloid or hypertrophic scars were significantly different. CONCLUSION: The large number of keratinocytes in keloid and basal layer of proliferating scar may express VEGF, which may be closely related to the formation of keloids and proliferative scar.