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目的 观察普米克 -令舒吸入治疗儿童急性喘息性疾病的疗效。方法 按统一标准选择患有急性喘息性疾病的 2 0 4名患儿 ,随机为二组 :治疗组 118例 ,给予普米克 -令舒雾化吸入并加入溴化异丙托品和全乐宁 (沙丁胺醇雾化溶液 ) ,对照组 86例给予强的松口服 ,并雾化吸入溴化异丙托品和全乐宁。观察用药前后患儿症状、体征改善情况 ,消失天数和部分患儿最大呼气流速值 (PEF)的变化。结果 治疗前后治疗组和对照组的患儿症状、体征均有明显改善。各组的临床症状消失时间 :治疗组 :呼吸困难 (2 6± 1 4 )d ,咳嗽 (6 1± 2 5 )d ,喘息 (3 0± 1 4d)d ,肺部体征 (4 7± 1 7)d ;对照组分别为 (4 2± 1 6 )d ,(8 6± 2 0 )d ,(4 2± 1 7)d ,(5 0± 1 9)d。另外治疗组和对照组 3岁以上患儿PEF治疗前分别为 (10 9± 2 1) ,(117± 19)L·min-1,治疗后分别为 (16 9± 12 ) ,(174± 16 )L·min-1。治疗组较对照组病程明显缩短 (P <0 0 5 ) ,3岁以上患儿PEF增加程度明显高于对照组。结论 对于儿童急性喘息性疾病在雾化吸入支气管扩张剂的同时 ,加用普米克 -令舒可使患儿症状和体征持续时间明显缩短 ,促进肺功能改善 ,从而缩短了治疗时间。
Objective To observe the curative effect of Pulmicort - Re Shu inhalation in children with acute asthmatic diseases. Methods A total of 204 children with acute asthmatic disease were selected according to uniform standards. The patients in the treatment group were randomly divided into two groups: 118 cases in the treatment group, inhaled with Pulmicort-Reshup and inhaled ipratropium bromide and All- (Albuterol nebulized solution), the control group of 86 cases given prednisone oral, and inhalation of ipratropium bromide and holly ning. Observed before and after treatment in children with symptoms, signs of improvement, disappear days and some children’s maximum expiratory flow rate (PEF) changes. Results Before and after treatment, the symptoms and signs of children in the treatment group and the control group were significantly improved. The disappearance time of clinical symptoms in each group was as follows: The treatment group had respiratory distress (26 ± 14 days), cough (61 ± 25 days), wheezing (30 ± 14 days), pulmonary signs (4 2 ± 1 6) d, (8 6 ± 2 0) d, (4 2 ± 1 7) d, (5 0 ± 1 9) d respectively. In addition, the PEF before and after treatment in children over 3 years old was (10 9 ± 2 1) and (117 ± 19) L · min -1 in the treatment group and the control group, respectively, after treatment was (16 9 ± 12) and (174 ± 16) ) L · min-1. The duration of treatment in the treatment group was significantly shorter than that in the control group (P <0.05). The PEF level in children over 3 years old was significantly higher than that in the control group. Conclusions In children with acute asthmatic disease, inhalation of bronchodilators in combination with Pulmicort-Ling Shu make the duration of symptoms and signs of children significantly shortened to promote the improvement of pulmonary function, thus shortening the treatment time.