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目的分析血清癌胚抗原(CEA)、糖链抗原CA199和CA724联合检测在胃癌诊断中的价值。方法选取2011年2月到2013年2月间收治的、经临床检查确诊为胃癌的84例患者,胃良性病变者80例,另选取80例健康人作为对照组。采用电化学发光法检测患者血清中CEA、CA199和CA724含量,分析CEA+CA199、CEA+CA724、CA199+CA724及CEA+CA199+CA724等不同组合联合方式的胃癌诊断价值。结果胃癌组患者血清中CEA、CA199和CA724含量分别为(48.1±21.2)ng/ml、(98.4±12.2)U/ml和(39.8±19.6)U/ml,均明显高于胃良性病变组和对照组,差异有统计学意义(P<0.05)。3项指标联合检测诊断胃癌的准确率为86.2%,特异度为88.9%,敏感度为84.1%,准确率和敏感度明显高于两种肿瘤标志物联合检测,差异有统计学意义(P<0.05)。3项指标不同组合方式联合检测的特异度无明显差异(P>0.05)。结论 CEA、CA199和CA724联合检测对胃癌诊断具有优越性,而对胃良性病变仅有一定的指导意义。
Objective To analyze the value of combined detection of serum carcinoembryonic antigen (CEA) and carbohydrate antigen CA199 and CA724 in the diagnosis of gastric cancer. Methods From February 2011 to February 2013, 84 patients diagnosed as gastric cancer by clinical examination, 80 patients with benign gastric lesions, and another 80 healthy people as the control group. The levels of CEA, CA199 and CA724 in serum of patients were detected by electrochemiluminescence. The diagnostic value of different combinations of CEA + CA199, CEA + CA724, CA199 + CA724 and CEA + CA199 + CA724 in gastric cancer was analyzed. Results The serum levels of CEA, CA199 and CA724 in gastric cancer patients were (48.1 ± 21.2) ng / ml, (98.4 ± 12.2) U / ml and (39.8 ± 19.6) U / ml, Control group, the difference was statistically significant (P <0.05). The accuracy of the combined detection of three indexes in the diagnosis of gastric cancer was 86.2%, the specificity was 88.9%, the sensitivity was 84.1%, the accuracy and sensitivity were significantly higher than those of the two tumor markers (P < 0.05). There was no significant difference in the specificity of the three tests with different combinations (P> 0.05). Conclusions The combined detection of CEA, CA199 and CA724 has the superiority in the diagnosis of gastric cancer, but only has certain guiding significance to benign gastric lesions.