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目的探讨血液中N-甲基氨甲酰加合物作为二甲基甲酰胺(DMF)职业接触标志物可行性。方法选择不同生产部门、不同DMF接触水平的职业人群87人,不接触DMF等有机溶剂的人员22人作为对照。气相色谱-质谱法测定N-甲基氨甲酰加合物经过一系列降解后的产物3-甲基-异丙基乙内酸脲(MVH)浓度。结果各类DMF职业接触人员血红蛋白中均检出了不同含量的MVH,而对照人群均未检出。血液中N-甲基氨甲酰加合物水平与DMF接触情况呈正相关。结论血液中N-甲基氨甲酰加合物有望成为反映DMF长期接触的标志物。
Objective To investigate the feasibility of using N-methylcarbamoyl adduct in blood as an occupational exposure marker for dimethylformamide (DMF). Methods 87 occupational groups with different production departments, different levels of exposure to DMF, and 22 non-contact DMF and other organic solvents were selected as controls. Gas chromatography-mass spectrometry (GC-MS) was used to determine the concentration of N-methylcarbamoyl adduct after a series of degradation of 3-methyl-isopropylacetates (MVH). Results There were different levels of MVH in hemoglobin of all kinds of occupational DMF workers, but not in the control group. The level of N-methylcarbamoyl adduct in blood is positively correlated with DMF exposure. Conclusion Blood N-methylcarbamoyl adduct is expected to become a marker of long-term exposure to DMF.