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目的：探讨丹参酮ⅡA对脑损伤、脑缺血或脑缺血再灌注诱导的小鼠的保护作用。方法采用小鼠断头模型、小鼠脑卒中模型、小鼠脑缺血再灌注模型，观察丹参酮ⅡA注射乳剂对小鼠断头后存活时间、喘气次数，小鼠脑卒中后的神经行为，小鼠脑缺血再灌注后脑内SOD活性、MDA含量的影响。结果丹参酮ⅡA能延长小鼠断头后的存活时间、增加断头后的喘气次数，改善脑卒中小鼠的神经行为，提高脑缺血再灌注损伤后小鼠脑组织中SOD酶活性，降低MDA含量。结论丹参酮ⅡA注射乳剂对小鼠脑缺血及脑缺血再灌注损伤具有保护作用。“,”ObJective To investigate TanⅡA brain inJury,cerebral ischemia or cerebral ischemia-reperfusion in mice induced protection. Methods decapitated mice model of stroke model in mice,mice with cerebral ischemia-reperfusion model was TanⅡA inJectable emulsion survival time of mice after decapitation,breathing frequency,neural behaviors mice after stroke,the small cerebral ischemia brain SOD activity, MDA content after reperfusion.Results TanⅡA inJectable emulsion can prolong the survival time of mice after decapitation, and increase the number of breath after decapitation, improve neurobehavioral stroke in mice,increased SOD activity, decreased MDA content.Conclusion TanⅡA emulsion inJection of mice with cerebral ischemia and cerebral ischemia-reperfusion inJury in rats.