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应用４种粘蛋白组化染色，观察了中国食管癌高发区中发生于食管中、上段的５４例６种亚型食管原发性腺癌（ＰＦＡ）以及正常食管腺体、Ｂａｒｒｅｔｔ食管的粘蛋白的性质和含量变化。发现ＰＥＡ粘蛋白为酸性粘蛋白，绝大多数ＰＥＡ酸性粘蛋白为唾液酸粘蛋白；正常食管固有腺粘蛋白亦为酸性粘蛋白，但以硫酸粘蛋白为主，而正常食管贲门腺和Ｂａｒｒｅｔｔ食管则主为中性粘蛋白。另外，还观察到食管鳞癌发生粘液样变时，粘蛋白为中性粘蛋白。据认为：①ＰＥＡ主要起源于食管固有腺导管；③唾液酸性蛋白增多是ＰＥＡ的组化特点；③唾液酸粘蛋白含量可能与肿瘤生物学行为有关。
Using 4 kinds of mucin histochemical staining, 54 cases of 6 types of esophageal primary adenocarcinoma (PFA) and normal esophageal glands, Barrett’s esophagus mucins in 54 cases of high esophageal cancer occurred in the middle and upper esophagus were observed. Changes in nature and content. The PEA mucin was found to be an acidic mucin. The vast majority of PEA acid mucins are sialic acid mucins; the normal esophageal innate glandular mucins are also acidic mucins, but mainly mucin sulfate, whereas the normal esophageal glands and Barrett’s esophagus The main is neutral mucin. In addition, mucin was also observed as a mucinous mucinous squamous cell carcinoma. It is thought that: 1PEA mainly originates from the esophageal intrinsic ducts; 3 increased salivary acidic protein is the histochemical feature of PEA; 3 the content of sialic acid mucin may be related to the biological behavior of tumors.