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富含精氨酸的载脂蛋白E是极低密度脂蛋白(VLDL)重要组分,在迄今检查过的人群中,至少有三种编码此种蛋白质的等位基因。已知一种等位基因(E_Ⅱ)表现纯合性,是发生Ⅲ型高脂蛋白血症的先决条件,故有必要研究在此位点其它基因型与发生冠心病风险的相关性。作者报告400名随机挑选的年龄在45～60岁(平均为53.0±0.22岁),生于英格兰东北Grampian地区正常人的基因频率,并与239名(其中男性194名,女性45名)65岁以下生于同一地区的心肌梗塞幸存者基因频率相比较。
Arginine-rich apolipoprotein E, an important component of very low density lipoprotein (VLDL), has at least three alleles encoding this protein in the human subjects examined so far. It is known that the homozygosity of an allele (E_II) is a prerequisite for the development of type III hyperlipoproteinemia, so it is necessary to study the relevance of other genotypes at this site to the risk of developing coronary heart disease. The authors report the frequency of 400 randomly selected individuals aged 45-60 (mean, 53.0 ± 0.22 years) born in the Grampian area of northeastern England, with 239 (including 194 males and 45 females) aged 65 years The following were born in the same area of myocardial infarction survivor gene frequency comparison.