芳香化酶是雄激素转化为雌激素的限速酶,其编码基因为CYP19基因,其表达具有组织特异性。在多种调控因素作用下,CYP19基因选择性地利用不同的启动子介导其在不同组织中的表达。在正常乳腺脂肪组织中,其表达由PI.4介导,而在乳腺癌中的表达主要通过PII,PI.3和PI.7启动;在造骨组织中,主要由PI.4,PI.3和PI.6介导。研究CYP19基因的组织特异性表达并利用基因治疗和/或药物干预等手段,能选择性地降低乳腺癌组织中的雌激素水平,减少其在骨质丢失和骨折等方面的不良作用。 Aromatase is a rate-limiting enzyme that converts androgens to estrogen. Its coding gene is the CYP19 gene and its expression is tissue-specific. Under various regulatory factors, CYP19 gene selectively uses different promoters to mediate its expression in different tissues. In normal breast adipose tissue, its expression is mediated by PI.4, while in breast cancer, it is mainly initiated by PII, PI.3 and PI.7; in osteoclast tissues, it is mainly composed of PI.4 and PI. 3 and PI.6 mediated. Research CYP19 gene tissue-specific expression and the use of gene therapy and / or drug intervention and other means, can selectively reduce the level of estrogen in breast cancer tissue, reducing its adverse effects on bone loss and fractures.