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神经毒力试验( NVT)是口服脊髓灰质炎疫苗( OPV)生产中的关键试验,按世界卫生组织( WHO)规程每个单价批OPV都要进行该项检测。由于猴子是脊髓灰质炎(脊灰)病毒的天然宿主,故至今NVT仍是在猴体上完成。1 990～1 991年WHO支持的两个实验室建立了携带人脊灰病毒受体的转基因小鼠。
Neurotoxicity test (NVT) is a key test in the production of oral polio vaccine (OPV), which is done per OPV according to the WHO protocol. Since monkeys are natural hosts of polio (polio) virus, so far NVT is still done on the monkey. Two laboratories supported by WHO from 1990 to 1991 established transgenic mice carrying human poliovirus receptors.