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目的 :验证穿琥中原料药精制前后动物的不良反应。方法 :取 2 4只豚鼠 ,随机分成两组 ,每组分别隔日注射 0 5mL(10 0mg/mL)的供试品 ,共3次 ,进行过敏反应实验。取 5 0只豚鼠 ,随机分为 5组 ,分别给予精制前后穿琥宁原料药 10 0mg /kg和 5 0mg/kg ,对照组给予生理盐水 ,观察排便。结果 :精制前的穿琥宁原料可使小鼠发生一级过敏发应 ,并有腹泻发生 ,而精制后的穿琥宁原料则无过敏和腹泻反应。
Objective : To verify the adverse reactions of animals before and after purification of raw materials in Chuanhu. METHODS: Twenty-four guinea pigs were randomly divided into two groups. Each group was injected with 0 mL (10 mg/mL) of the test sample every other day for 3 times. Allergic reactions were performed. A total of 50 guinea pigs were randomly divided into 5 groups. Raw and processed Chuanhuning raw materials before and after refining were given 10mg/kg and 50mg/kg respectively. The control group was given saline and defecation was observed. RESULTS: The raw materials of Chuanhuning before refining could cause first-degree allergy and diarrhea in mice, while the purified Chuanhuning raw materials had no allergic and diarrhea reactions.